What is a typical symptom of asthma exacerbated by histamine?

Wheezing is a hallmark symptom associated with asthma, particularly during an exacerbation. In asthma, histamine plays a crucial role as a mediator of inflammation and bronchoconstriction. When histamine is released in the lungs, it causes the smooth muscles around the airways to constrict, leading to narrowing of the air passages. This constriction, along with increased mucus production and airway swelling, culminates in the characteristic wheezing sound during breathing.

Wheezing indicates that the airways are partially obstructed, making it more challenging for air to move in and out of the lungs. This symptom is often assessed during an asthma attack and is a crucial sign that an individual is experiencing significant respiratory distress. Understanding wheezing as a symptom recognizes its association with the underlying pathophysiology of asthma exacerbation, where inflammation and bronchial hyperreactivity are exacerbated.