What physiological change can histamine induce during an asthma attack?

During an asthma attack, histamine plays a critical role in the pathophysiological changes that contribute to airway obstruction. Histamine is a potent mediator of allergic responses and has several effects on the respiratory system. Its release during an asthma attack leads to bronchoconstriction, which is the tightening of the smooth muscles surrounding the airways, resulting in narrowing of the airways. This narrowing increases airflow resistance, making it difficult for individuals to breathe and often leading to symptoms such as wheezing, coughing, and shortness of breath.

Additionally, histamine contributes to inflammation and increased mucus production within the airways, further exacerbating the narrowing. This complex interplay between bronchoconstriction and inflammation underscores the importance of understanding histamine's effects during an asthma attack, as managing these symptoms is crucial for effective treatment and prevention of attacks.