When administering gentamicin to a child with cystic fibrosis, which action is most crucial?

When administering gentamicin to a child with cystic fibrosis, monitoring intake and output is crucial for several reasons. Gentamicin is an aminoglycoside antibiotic that can potentially have nephrotoxic effects, particularly in children with cystic fibrosis, who may already be at risk for renal impairment due to various factors related to their condition, including possible dehydration and the effects of the disease itself on kidney function.

Closely monitoring fluid intake and output helps assess renal function and kidney health. It’s essential to ensure that the child is maintaining proper hydration and to observe for any signs of fluid overload or deficit that may affect drug clearance. This approach allows for timely interventions if renal function deteriorates, which can be indicated by changes in urine output.

In the context of administering gentamicin, attention to renal function through monitoring intake and output becomes particularly vital as dosage adjustments may be required based on kidney performance to avoid toxicity.